Intrinsic DILI: This is where a drug and/or drug metabolites induce liver toxicity in a predicted and dose-dependent manner. Most individuals show a response at some dose, and the toxicity levels are ...

A version of this story appeared in Volume 103, Issue 11 Chemists and chemical biologists just keep dreaming up new ways to interfere with biomolecules. That research frequently leads to promising ...

After identifying three different types of resistance to a promising investigational lung cancer drug in a phase 1 trial, a team of researchers led by Dana-Farber Cancer Institute scientists say new ...

The FDA's orphan drug designation supports LP-284's development for soft tissue sarcomas, addressing significant unmet needs in this adult patient population. The FDA granted orphan drug designation ...

Lipids have become indispensable to modern drug delivery offering a versatile toolkit for the formulation and transport of therapeutic agents. Over the past two decades, the field has experienced ...

Triple-negative breast cancer (TNBC) is among the most aggressive types of breast cancer, lacking estrogen, progesterone, and HER2 receptors and thus relying primarily on cytotoxic chemotherapy.

There are two types of blood pressure medications that cause higher variability in blood pressure measurements between physician appointments visits, which is associated with an increased mortality ...

A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture. Grown ...

The authors examine how insurer and patient out-of-pocket payments for advanced prostate cancer differ by drug and health plan type and describe the relationship between these payments and utilization ...