In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

PythoC lets you use Python as a C code generator, but with more features and flexibility than Cython provides. Here’s a first look at the new C code generator for Python. Python and C share more than ...

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Computer programming powers modern society and enabled the artificial intelligence revolution, but little is known about how our brains learn this essential skill. To help answer that question, Johns ...

Games can be a great way to learn real-life skills. Minecraft is often held up as a fantastic tool for encouraging creativity, and Stardew Valley teaches good habits for time management. The Farmer ...

One of the more intriguing legendary weapons in the game is one that is returning from Borderlands 3, and it is called the Complex Root. This strange sniper rifle doesn't fire a normal projectile, but ...

SIlent Hill f's locker code puzzle expects you to think creatively about numbers and letters. The game's "girl code" swaps letters for numbers that look similar, so 4 stands in for the letter A and 3 ...

The dental procedure is one of the most dreaded. Here are six of its most common causes. By Susan Shapiro Last fall, I was plagued by a mysterious string of toothaches. Several dental appointments and ...

A tool can be used well or poorly, but much of the time it is neither inherently good nor bad. Take vibe coding, the act of using natural language to instruct an LLM to generate code. Applied poorly, ...

From top-tier mil-sim Operators to nearly invisible ghillie suits, here are the best Operator skins to use in Call of Duty: Warzone. The first and arguably most difficult step of the Easter Egg is to ...

Anthropic launched learning modes in Claude chatbot and Claude Code. Instead of creating answers, they use the Socratic approach to guide you. You can select 'Learning' from the style dropdown to ...